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Cyp7b1

Cyp7b1

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View mouse Cyp7b1 Chr3:18071950-18243338 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression cyp7b1 builds an enzyme that is involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids

GoPubMed lists recent and important papers and reviews for cytochrome P450, family 7, subfamily B, polypeptide 1(CYP7B1) View unique variants in gene CYP7B1; View all variants in gene CYP7B1; Full data view for gene CYP7B1; View all individuals; View all individuals with variants in gene CYP7B1 Bioclone provides recombinant protein codon optimized cDNA clone for O75881 CYP7B1 Cytochrome P450 7B1 (EC 1

HGNC approved symbol report for the gene CYP7B1 (HGNC_ID:2652) Buy cyp7b1 antibodies from Santa Cruz Biotechnology, Inc

The disease presents with progressive stiffness and contraction in the lower limbs

24889-1-AP detected 50-55 kDa band in A431 cells with 1:500-1:2000 dilution In this strain, a neomycin resistance cassette replaces part of exon 6 of the endogenous Cyp7b1 gene

External References: Wikipedia GeneCards HUGO COSMIC Google Scholar NCBI Description of CYP7B1: This gene encodes a member of the cytochrome P450 superfamily of enzymes

The CYP7B1 gene provides instructions for making an enzyme called oxysterol 7-alpha-hydroxylase CYP7B1

View Cyp7b1<tm1a(EUCOMM)Wtsi> allele: origin, molecular description, gene associations, and references

An antibody specific for CYP7B1 has been pre-coated onto a microplate

Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a Since this is your first visit to the site, you are seeing this message

The Bile Acid Synthesis Pathway Is Present and Functional in the Human Ovary (Panel C, image 1), CYP7B1 (Panel C, image 2), and CYP8B1 (Panel C, Bialllelic mutations in the CYP7B1 gene (8q12

Hydroxylation reduces the biological activity of these substrates and facilitates their conversion to end products that are readily excreted from the body

Every primer pair is optimized, experimentally validated, and performance guaranteed

These mice are useful for studying cholesterol and bile acid metabolism, oxysterol synthesis and breakdown, macrophage function, and B cell trafficking and activation in the immune system

Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a Buy CYP7B1 sirna-NP_031851

Enzymes produced from cytochrome P450 genes are involved in the formation and breakdown of various molecules and chemicals within cells

REPORT Sequence Alterations within CYP7B1 Implicate Defective Cholesterol Homeostasis in Motor-Neuron Degeneration Maria K

Because most exposure to environmentally persistent organic pollutants (POPs) occurs through the diet

MABS513, used in Immunohistochemistry (Paraffin) and Western Blotting

100) (25-hydroxycholesterol 7-alpha-hydroxylase) (Oxysterol 7-alpha-hydroxylase) Inflammasome Activation by Chronic Down Regulation of CYP7B1 and its Causative Increased Oxysterol Accumulation, Sequence Alterations within CYP7B1 Implicate Defective Cholesterol Homeostasis in Motor-Neuron Degeneration Genes Tested: AKR1D1, CYP7B1, HSD3B7

CYP7B1 Antibody 24889-1-AP has been identified with IF, IHC, WB, ELISA

This gene provides instructions for making an enzyme called oxysterol 7-alpha-hydroxylase

CYP7B1 is a member of the cytochrome P450 superfamily of monooxygenases, involved in the metabolism of cholesterol, neurosteroids, and other lipids

MyBioSource offers the widest selection of antigen, biochemical, peptide, cdna, clia, pcr, sirna, recombinant protein, antibody, elisa kit products

Based on automated MP annotations supported by experiments on knockout mouse models

Use Bio-Rad's PrimePCR assays, controls, templates for your target gene

This gene encodes a member of the cytochrome P450 superfamily of enzymes

CYP7B1 Antibody (WW-H9) is a high quality mouse monoclonal recommended for detecting CYP7B1 of human origin by WB, IP and ELISA 25-hydroxycholesterol 7-alpha-hydroxylase also known as oxysterol and steroid 7-alpha-hydroxylase is an enzyme that in humans is encoded by the CYP7B1 gene

Complete information for CYP7B1 gene (Protein Coding), Cytochrome P450 Family 7 Subfamily B Member 1, including: function, proteins, disorders, pathways, orthologs, and expression

Plays a key role in cell positioning and movement in lymphoid tissues: 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a Shop for CYP7B1 elisa kit, antibody, protein

Ab45557 is a blocking peptide for ab19043 and has been validated in BL

Researchers discover new driver of breast cancer Date "Measurements of tumor CYP7B1 or 27HC content could provide a potentially critical new means to Tested Applications: Immunohistochemistry, Western

Autosomal recessive fo Transient transfection assays of CYP7B1 promoter/luciferase reporter constructs Structure and functions of human oxysterol 7α-hydroxylase cDNAs and gene Spastic paraplegia type 5A is caused by mutations in the CYP7B1 gene

Also, plays a role in the transformation of cholesterol to bile acids

Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol (PubMed:9295351)

Spastic paraplegia-5A is an autosomal recessive neurologic disorder with a wide phenotypic spectrum

CYP7B1 is expressed in the liver protein-coding gene in the species Homo sapiens CYP7B1 Recombinant Protein Antigen

Reporter tagging of the Cyp7b1 gene demonstrated that the enzyme is widely expressed, particularly strongly in brain, liver, liver, kidney, heart, and spleen

It is found in many parts of the body, as shown in the below table (Table 1)

Box 27069, Decreased hepatotoxic bile acid composition and altered synthesis in progressive Increased mRNA expression of BAAT and CYP7B1 was observed in contrast to Antibody [NBP2-50217B] CYP7B1 Antibody (M17-P3F2) [Biotin] [Mouse Monoclonal] by Novus Biologicals Cancer3D is a database that unites information on somatic missense mutations from TCGA and CCLE, allowing users to explore two different cancer-related problems at Background: Alteration of the gut microbiota through diet and environmental contaminants may disturb physiological homeostasis, leading to various diseases including obesity and type 2 diabetes

The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids

In the brain, oxysterol 7-alpha-hydroxylase is involved in a pathway that converts cholesterol to hormones called neurosteroids

100) (25-hydroxycholesterol 7-alpha-hydroxylase) (Oxysterol 7-alpha-hydroxylase) Sequence Alterations within CYP7B1 Implicate Defective Cholesterol Homeostasis in Motor-Neuron Degeneration protein-coding gene in the species Mus musculus Detect CYP7B1 using this mouse monoclonal Anti-CYP7B1 Antibody, clone M17P3F2, Cat

The CYP7B1 gene is a member of the cytochrome P450 gene family

We analyzed the frequency of two previously described CYP7B1 You have free access to this content Human steroid and oxysterol 7α-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants Gene symbol: Chromosomal location: Gene name: Mutation total: Log in: CYP7B1: 8q21

MOTOR NEURON DISEASE TESTING SERVICES Important Gene Tests for Hereditary Spastic Paraplegia Hereditary Spastic Paraplegia (HSP) SPG3A SPG4 CYP7B1 The retinoid-related orphan receptors (RORs) and liver X receptors (LXRs) were postulated to have distinct functions

3: Cytochrome p450, subfamily VIIB (oxysterol 7 alpha-hydroxylase), polypeptide 1 Our Distributors; Our Distributors Australia

CYP7B1 is an appealing candidate for this due to its contribution to antiviral immune responses

These estrogenic functions of DHT are mediated by its metabolite 5α-androstane-3β, 17β-diol (3β-diol) binding to estrogen receptor β (ERβ)

Additionally, the CYP7B1 has preliminary evidence supporting a correlation with autosomal recessive congenital bile acid synthesis defect type 3 (CBAS3) (MedGenUID: 462497)

Simpson, You have free access to this content Human steroid and oxysterol 7α-hydroxylase CYP7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants CYP7B1 Uncomplicated/Complicated AR Spastic paraplegia 5A Test Information Sheet 207 Perry Parkway, Gaithersburg, MD 20877 | P: 301-519-2100 HSPP : Diagnosis of hereditary spastic paraplegia with neuropathy associated with known causal genes Second-tier testing for patients in whom previous targeted gene mutation analyses for specific inherited hereditary spastic paraplegia-related genes were negative &nbsp; Identifying mutations within genes known to be associated with hereditary View Cyp7b1<tm1a(EUCOMM)Wtsi> allele: origin, molecular description, gene associations, and references

In addition to androgenic properties mediated via androgen receptors, dihydrotestosterone (DHT) also regulates estrogenic functions via an alternate In addition to androgenic properties mediated via androgen receptors, dihydrotestosterone (DHT) also regulates estrogenic functions via an alternate pathway

Monoclonal antibodies are available to most protein immunogens

Application: RNA Interference (RNAi) CYP7B1 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, CYP7B1 Genome Browser, CYP7B1 References Abstract

RORs play a role in tissue development and circadian rhythm, whereas LXRs are sterol sensors that affect lipid homeostasis

CYP7B1 is an enzyme that is used in many different body functions and is best known for its work in bile salt synthesis

Immunogen corresponding to synthetic peptide CYP7B1 (cytochrome P450, family 7, subfamily B, polypeptide 1), Authors: Maria Norlin

The CYP7B1 cytochrome P450 enzyme hydroxylates carbons 6 and 7 of the B ring of oxysterols and steroids

Libro de Hugo Richard Villanueva Lungasso Early onset of puberty and early ovarian failure in CYP7B1 knockout mice Yoko Omoto*, Richard Lathe†, Margaret Warner*, and Jan-Åke Gustafsson*‡ *Departments of Medical Nutrition and Bioscience, Karolinska Institute, 141 86 Huddinge, Sweden; and †Pieta Research, P

CYP7B1 is the enzyme responsible for hydroxylation and termination of the estrogenic actions of the androgen metabolite, The National Academy of Sciences; Complete information for CYP7A1 gene (Protein Coding), Cytochrome P450 Family 7 Subfamily A Member 1, including: function, proteins, disorders, pathways, orthologs, and expression

Oxysterol 7alpha-hydroxylase that mediates formation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) from 25-hydroxycholesterol (PubMed:10588945)

Some patients An endocrine pathway in the prostate, ERβ, AR, 5α-androstane-3β,17β-diol, and CYP7B1, regulates prostate growth CYP7A1, CYP7B1: CYP8: varied: 2 subfamilies, 2 genes: CYP8A1 (prostacyclin synthase), CYP8B1 (bile acid biosynthesis) CYP11: steroid biosynthesis: 2 Antibody [NBP2-50217JF549] CYP7B1 Antibody (M17-P3F2) [Janelia Fluor® 549] [Mouse Monoclonal] by Novus Biologicals CYP7B1 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, CYP7B1 Genome Browser, CYP7B1 References Reporter tagging of the Cyp7b1 gene demonstrated that the enzyme is widely expressed, particularly strongly in brain, liver, liver, kidney, heart, and spleen

Detect CYP7B1 using this mouse monoclonal Anti-CYP7B1 Antibody, clone M17P3F2, Cat

Martin, HGNC approved symbol report for the gene CYP7B1 (HGNC_ID:2652) Buy cyp7b1 antibodies from Santa Cruz Biotechnology, Inc

603711 - cytochrome p450, family 7, subfamily b, polypeptide 1; cyp7b1 - oxysterol 7-alpha-hydroxylase 1 - cyp7b1 The CYP7B1 gene is associated with autosomal recessive hereditary spastic paraplegia type 5A (SPG5A) (MedGen UID: 376521)

Application: RNA Interference (RNAi) Hereditary spastic paraplegia (HSP) is a group of inherited diseases whose main feature is a progressive gait disorder

The Invitae Hereditary Spastic Paraplegia Comprehensive Panel analyzes up to 64 genes associated with hereditary spastic paraplegia ATL1, CYP7B1, K1F5A, REEP1, CYP27A1 A gene on chromosome 2q33-qter that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of c Bioclone provides recombinant protein codon optimized cDNA clone for O75881 CYP7B1 Cytochrome P450 7B1 (EC 1

Abcam provides free protocols, tips and expert support… This gene encodes a member of the cytochrome P450 superfamily of enzymes

A number sign (#) is used with this entry because spastic paraplegia-5A (SPG5A) is caused by homozygous or compound heterozygous mutation in the CYP7B1 gene (603711) on chromosome 8q12

27-Hydroxycholesterol (27OH) is a strong suppressor of cholesterol synthesis and a weak activator of LXR in vitro

Rabbit polyclonal CYP7B1 antibody validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human

3) have been identified in this disorder resulting in a marked accumulation of neurotoxic oxysterols in plasma and CSF

Here we utilized male mice with increased levels of 27OH either due to increased production (CYP27A1 transgenic mice) or reduced metabolism (Cyp7b1-/- mice)

CYP7B1 Polyclonal Antibody from Invitrogen for Western Blot, Immunofluorescence, Immunocytochemistry and Immunohistochemistry (Paraffin) applications

(A–C) Changes of hepatic steatosis in the liver of control and experimental mice as measured by liver triglyceride le Journal of Lipid Research Volume 40, 1999 2195 Structure and functions of human oxysterol 7 a-hydroxylase cDNAs and gene CYP7B1 Zhengliang Wu,* K

Congenital bile acid synthesis defect is an autosomal recessive condition associated with neonatal onset liver disease

We analyzed the frequency of two previously described CYP7B1 CYP7B1 is an enzyme that works to hydrolyze many different molecules of cholesterol synthesis, including 27HC

NDEx, the Network Data Exchange, is a collaborative software infrastructure for storing, sharing and publishing biological network knowledge; NDEx is developed in tight association with Cytoscape at the UC San Diego School of Medicine

Thirty-four different loci for hereditary spastic paraplegias have been mapped, and 16 responsible genes have been identified

However, for our project, we are going to focus on the CYP7B1’s function in the metabolism of estrogen receptor ligands and cholesterol metabolites, such as 27HC

Test principle This assay employs a two-site sandwich ELISA to quantitate CYP7B1 in samples